Animal Reproduction (AR)
https://animal-reproduction.org/article/doi/10.1590/1984-3143-AR2022-0012
Animal Reproduction (AR)
ORIGINAL ARTICLE

Application of PGF at the moment of fixed-time artificial insemination in crossbred beef cows

Jéssica Cristina dos Santos Marques; Gustavo Pereira Cadima; Ana Cláudia Fagundes Faria; Eduarda Arruda Guimarães; Fabiana Silva Oliveira; Ricarda Maria dos Santos

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Abstract

Although studies have shown positive effects of gonadotropin releasing hormone (GnRH) or prostaglandin F (PGF) at the moment of fixed-time artificial insemination (FTAI) in the conception rate (CR) of cattle, its effects on treatments based on progesterone (P4) and estradiol benzoate (EB) is still not conclusive. The objective of this study was (1) to evaluate the effect of a PGF analogue at FTAI in the CR of crossbred beef cows submitted to a 11d FTAI protocol based on P4 and EB; and (2) to describe the CR between PGF-treated and control cows in different body condition scores (BCS) and parity categories. Crossbred (½ Nellore and ½ Angus) beef cows were submitted to a synchronization protocol and randomly assigned into 2 groups: Control (n = 163), at FTAI cows received 2 mL of saline solution as a placebo, and PGF (n = 163), at FTAI cows were treated with PGF analogue (10 mg of dinoprost tromethamine). Pregnancy diagnosis was performed 33d post-FTAI. Binary logistic regression model was used to analyze the effect of PGF treatment on CR. There was no difference in CR between PGF and control groups (P > 0.05; odds ratio (OR) = 0.92; confidence interval (CI) = 0.59-1.4). A greater CR was found in heifers (P = 0.0006, OR = 2.65, CI = 1.61 - 4.38) and multiparous (P = 0.0006, OR = 2.12, CI = 1.04 - 4.3) when compared to primiparous cows. Cows with low BCS (4; 9-point scale) showed lower CR when compared with moderate BCS (5-6; 9-point scale) (P < 0.05; OR = 0.10; CI = 0.06 - 0.18). There was no numerical difference on CR between PGF-treated and control cows in different BCS and parity categories. The results suggested that the CR in this study was not influenced by 10 mg PGF analogue at FTAI.

Keywords

FTAI, pregnancy, PGF, conception rate, beef cows

References

Ambrose DJ, Gobikrushanth M, Zuidhof S, Kastelic JP. Low-dose natural prostaglandin F2α (dinoprost) at timed insemination improves conception rate in dairy cattle. Theriogenology. 2015;83(4):529-34. http://dx.doi.org/10.1016/j.theriogenology.2014.10.034. PMid:25434776.

Archbald LF, Tran T, Massey R, Klapstein E. Conception rates in dairy cows after timed-insemination and simultaneous treatment with gonadotrophin releasing hormone and/or prostaglandin F2 alpha. Theriogenology. 1992;37(3):723-31. http://dx.doi.org/10.1016/0093-691X(92)90151-G. PMid:16727073.

Baruselli PS, Sales JNS, Sala RV, Vieira LM, Sá MF Fo. History, evolution and perspectives of timed artificial insemination programs in Brazil. Anim Reprod. 2012;9(3):139-52.

Binelli M, Machado R, Bergamaschi M, Silva J, Ibiapina B, Bisinotto R. Conceitos e aplicações de estratégias antiluteolíticas visando o incremento da taxa de concepção em bovinos. In: 2º Simpósio Internacional de Reprodução Animal Aplicada; 2006 Oct 5-7; Londrina, Brazil. São Paulo: USP; 2006. pp. 93-100.

Borges J. Tópicos de manejo reprodutivo em rebanhos de corte. In: XII Ciclo de Palestras em Produção e Manejo de Bovinos; 2016 May 15-18; Canoas,Brazil. Canoas: ULBRA; 2007. pp. 7-26.

Bridges GA, Mussard ML, Helser LA, Day ML. Comparison of follicular dynamics and hormone concentrations between the 7-day and 5-day CO-Synch + CIDR program in primiparous beef cows. Theriogenology. 2014;81(4):632-8. http://dx.doi.org/10.1016/j.theriogenology.2013.11.020. PMid:24388673.

Burnett TA, Polsky L, Kaur M, Cerri RLA. Effect of estrous expression on timing and failure of ovulation of Holstein dairy cows using automated activity monitors. J Dairy Sci. 2018;101(12):11310-20. http://dx.doi.org/10.3168/jds.2018-15151. PMid:30268619.

Diniz JHW, Peres RFG, Teixeira ACB, Riveros JAN, Noronha IM, Martins CFG, Oliveira CS, Pohler KG, Pugliesi G, Oliveira LZ. Administration of PGF2α at the moment of timed-AI using sex-sorted or conventional semen in suckled nelore cows with different intensity of estrus behavior. Theriogenology. 2021;174:169-75. http://dx.doi.org/10.1016/j.theriogenology.2021.08.023. PMid:34455244.

Diskin MG, Mackey DR, Roche JF, Sreenan JM. Effects of nutrition and metabolic status on circulating hormones and ovarian follicle development in cattle. Anim Reprod Sci. 2003;78(3-4):345-70. http://dx.doi.org/10.1016/S0378-4320(03)00099-X. PMid:12818653.

Gabriel HG, Wallenhorst S, Dietrich E, Holtz W. The effect of prostaglandin F2α administration at the time of insemination on the pregnancy rate of dairy cows. Anim Reprod Sci. 2011;123(1-2):1-4. http://dx.doi.org/10.1016/j.anireprosci.2010.11.010. PMid:21167663.

Gottschall CS, Bittencourt HR, Mattos RC, Gregory RM. Antecipação da aplicação de prostaglandina, em programa de inseminação artificial em tempo fixo em vacas de corte. Rev Bras Saúde Prod Anim. 2009;10(4):1543.

Grillo G, Guimarães A, Couto S, Figueiredo M, Palhano H. Comparison of pregnancy rate between heifers, primiparous and multiparous Nellore submitted to artificial insemination fixed time. Braz J Vet Med. 2015;37(3):193.

Hawk HW. Sperm survival and transport in the female reproductive tract. J Dairy Sci. 1983;66(12):2645-60. http://dx.doi.org/10.3168/jds.S0022-0302(83)82138-9. PMid:6365994.

Hiers EA, Barthle CR, Dahms MKV, Portillo GE, Bridges GA, Rae DO, Thatcher WW, Yelich JV. Synchronization of Bos indicus × Bos taurus cows for timed artificial insemination using gonadotropin-releasing hormone plus prostaglandin F in combination with melengestrol acetate. J Anim Sci. 2003;81(4):830-5. http://dx.doi.org/10.2527/2003.814830x. PMid:12723069.

Hunter RHF. Physiology of the graafian follicle and ovulation. Cambridge: Cambridge University Press; 2003. VIII The process of ovulation and shedding of an oocyte; p. 262-94.

Imakawa K, Day ML, Zalesky DD, Clutter A, Kittok RJ, Kinder JE. Effects of 17β-estradiol and diets varying in energy on secretion of luteinizing hormone in beef heifers. J Anim Sci. 1987;64(3):805-15. http://dx.doi.org/10.2527/jas1987.643805x. PMid:3571004.

Leonardi CEP, Pfeifer LFM, Rubin MIB, Singh J, Mapletoft RJ, Pessoa GA, Bainy AM, Silva CAM. Prostaglandin F2α promotes ovulation in prepubertal heifers. Theriogenology. 2012;78(7):1578-82. http://dx.doi.org/10.1016/j.theriogenology.2012.06.030. PMid:22925644.

López-Gatius F, Yániz JL, Santolaria P, Murugavel K, Guijarro R, Calvo E, López-Béjar M. Reproductive performance of lactating dairy cows treated with cloprostenol at the time of insemination. Theriogenology. 2004;62(3-4):677-89. http://dx.doi.org/10.1016/j.theriogenology.2003.11.014. PMid:15226022.

Luz GB, Maffi AS, Farias LB, Xavier EG, Lima ME, Corrêa MN, Brauner CC. Effects of the bull on conception rate of dairy cows in different seasons and according to AI type. Acta Sci Vet. 2018;46(1):6. http://dx.doi.org/10.22456/1679-9216.82554.

Madureira AML, Polsky LB, Burnett TA, Silper BF, Soriano S, Sica AF, Pohler KG, Vasconcelos JLM, Cerri RLA. Intensity of estrus following an estradiol-progesterone-based ovulation synchronization protocol influences fertility outcomes. J Dairy Sci. 2019;102(4):3598-608. http://dx.doi.org/10.3168/jds.2018-15129. PMid:30738666.

Madureira AML, Silper BF, Burnett TA, Polsky L, Cruppe LH, Veira DM, Vasconcelos JLM, Cerri RLA. Factors affecting expression of estrus measured by activity monitors and conception risk of lactating dairy cows. J Dairy Sci. 2015;98(10):7003-14. http://dx.doi.org/10.3168/jds.2015-9672. PMid:26254517.

Martins T, Talamoni JP, Sponchiado M, Maio JRG, Nogueira GP, Pugliesi G, Binelli M. Impact of estradiol cypionate prior to TAI and progesterone supplementation at initial diestrus on ovarian and fertility responses in beef cows. Theriogenology. 2017;104:156-63. http://dx.doi.org/10.1016/j.theriogenology.2017.08.017. PMid:28846912.

Meneghetti M, Sá OG Fo, Peres RFG, Lamb GC, Vasconcelos JLM. Fixed-time artificial insemination with estradiol and progesterone for Bos indicus cows I: basis for development of protocols. Theriogenology. 2009;72(2):179-89. http://dx.doi.org/10.1016/j.theriogenology.2009.02.010. PMid:19344942.

Noronha IM, Cooke RF, Martins CFG, Oliveira RV Fo, Pohler KG, Vasconcelos JLM. Administering an additional prostaglandin F2α injection to Bos indicus beef cows during a treatment regimen for fixed-time artificial insemination. Anim Reprod Sci. 2020;219:106535. http://dx.doi.org/10.1016/j.anireprosci.2020.106535. PMid:32828410.

Osoro K, Wright IA. The effect of body condition, live weight, breed, age, calf performance, and calving date on reproductive performance of spring-calving beef cows. J Anim Sci. 1992;70(6):1661-6. http://dx.doi.org/10.2527/1992.7061661x. PMid:1634389.

Pereira TD, Santos BC, Neves GZF. Variabilidade pluviométrica do estado do Mato Grosso na série temporal de 1998 a 2017. Rev GeoNorte. 2020;11(37):39-56. http://dx.doi.org/10.21170/geonorte.2020.V.11.N.37.39.56.

Pfeifer LFM, Rodrigues WB, Silva KC, Anache NA, Castro NÁ, Castilho EM, Nogueira E. Different protocols using PGF2α as ovulation inducer in Nelore cows subjected to estradiol-progesterone timed AI based protocols. Theriogenology. 2018;120:56-60. http://dx.doi.org/10.1016/j.theriogenology.2018.06.030. PMid:30092375.

Pitchford WS, Pitchford JM, Alexopoulos JG, Hebart ML. Genomic analysis of purebred and crossbred Angus cows quantifies heterozygosity, breed, and additive effects on components of reproduction. Animals. 2022;12(1):61. http://dx.doi.org/10.3390/ani12010061. PMid:35011167.

Pryce JE, Coffey MP, Simm G. The relationship between body condition score and reproductive performance. J Dairy Sci. 2001;84(6):1508-15. http://dx.doi.org/10.3168/jds.S0022-0302(01)70184-1. PMid:11417711.

Randel RD, Lammoglia MA, Lewis AW, Neuendorff DA, Guthrie MJ. Exogenous PGF2α enhanced GnRH-induced LH release in postpartum cows. Theriogenology. 1996;45(3):643-54. http://dx.doi.org/10.1016/0093-691X(95)00410-A. PMid:16727826.

Sá MF Fo [homepage on the internet]. Cachoeira Paulista: Master Genetics; 2012 [cited 2022 Oct 10]. Available from: http://www.mastergenetics.com.br/wp-content/uploads/2012/05/Efeito-individual-de-touros.pdf

Sá MF Fo, Penteado L, Reis EL, Reis TANPS, Galvão KN, Baruselli PS. Timed artificial insemination early in the breeding season improves the reproductive performance of suckled beef cows. Theriogenology. 2013;79(4):625-32. http://dx.doi.org/10.1016/j.theriogenology.2012.11.016. PMid:23261306.

Sales JNS, Crepaldi GA, Girotto RW, Souza AH, Baruselli PS. Fixed-time AI protocols replacing eCG with a single dose of FSH were less effective in stimulating follicular growth, ovulation, and fertility in suckled-anestrus Nelore beef cows. Anim Reprod Sci. 2011;124(1-2):12-8. http://dx.doi.org/10.1016/j.anireprosci.2011.02.007. PMid:21376482.

Stolla R, Schmid G. Effects of natural and synthetic PGF2a preparations on theuterine contractility of cattle. Berl Munch Tierarztl Wochenschr. 1990;103(6):198-202. PMid:2383227.

Wagner JJ, Lusby KS, Oltjen JW, Rakestraw J, Wettemann RP, Walters LE. Carcass composition in mature hereford cows: estimation and effect on dally metabolizable energy requirement during winter. J Anim Sci. 1988;66(3):603-12. http://dx.doi.org/10.2527/jas1988.663603x. PMid:3378920.

Wathes DC, Cheng Z, Bourne N, Taylor VJ, Coffey MP, Brotherstone S. Differences between primiparous and multiparous dairy cows in the inter-relationships between metabolic traits, milk yield and body condition score in the periparturient period. Domest Anim Endocrinol. 2007;33(2):203-25. http://dx.doi.org/10.1016/j.domaniend.2006.05.004. PMid:16806790.

Weems CW, Weems YS, Randel RD. Prostaglandins and reproduction in female farm animals. Vet J. 2006;171(2):206-28. http://dx.doi.org/10.1016/j.tvjl.2004.11.014. PMid:16490704.
 


Submitted date:
01/24/2022

Accepted date:
10/10/2022

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