Animal Reproduction (AR)
https://animal-reproduction.org/article/doi/10.1590/1984-3143-AR2022-0109
Animal Reproduction (AR)
ORIGINAL ARTICLE

Influence of prenatal corticosteroid therapy on neonatal vitality and utility as a labor-inducing agent in Santa Inês ewes

Elisiane Sateles dos Santos; Rodrigo Freitas Bittencourt; Gleice Mendes Xavier; Carmo Emanuel Almeida Biscarde; Isabella de Matos Brandão Carneiro; Mateus Martins Rodrigues dos Santos; Antonio de Lisboa Ribeiro Filho

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Abstract

Abstract: Since the 1970s, maternal corticosteroid therapy has been used successfully to induce labor. This allows for better monitoring of parturients and provision of first aid to neonates, improving neonatal viability, as this treatment induces maturation in a variety of fetal tissues, thereby reducing morbidity and mortality. Although the effects of corticosteroids are well known, few studies have investigated the influence of this therapy in Santa Inês sheep. This study aimed to evaluate the efficacy of dexamethasone at two doses (8 and 16 mg) to induce lambing in Santa Inês ewes at 145 days of gestation and assess its effects on neonatal vitality. For this study, 58 ewes raised in an extensive system were investigated. Pregnancy was confirmed after artificial insemination at a set time or after controlled mounting. Ewes were separated into three groups: an untreated control group (G1: 0 mg) and groups treated with two doses of dexamethasone (G2: 8 mg and G3: 16 mg). In total, 79 lambs were born. Their vitality was assessed based on their Apgar score, weight, temperature, and postnatal behavior. SAS v9.1.3 (SAS Institute, Cary, NC) was used to analyze data, considering a 5% significance level for all analyses. The births in the induced groups occurred 48.4 ± 22.1 h after induction, while the ewes that underwent non-induced labor gave birth 131.96 ± 41.9 h after placebo application (p < 0.05), confirming the efficacy of dexamethasone to induce and synchronize labor. The induced and non-induced neonates had similar Apgar scores, temperatures, weights, and postnatal behavioral parameters (p > 0.05). This study showed that inducing labor in Santa Inês ewes at 145 days of gestation with a full (16 mg) or half dose (8 mg) of dexamethasone is an effective technique and does not compromise neonate vitality.

Keywords

corticosteroid, parturient, reproductive biotechnology, sheep

References

Adams WM, Wagner C. The role of corticoids in parturition. Biol Reprod. 1970;3(2):223-8. http://dx.doi.org/10.1093/biolreprod/3.2.223. PMid:5522854.

Ballard PL, Ning Y, Polk D, Ikegami M, Jobe AH. Glucocorticoid regulation of surfactant components in immature lambs. Am J Physiol. 1997;273(5):L1048 -57. http://dx.doi.org/10.1152/ajplung.1997.273.5.L1048. PMid:9374734.

Barr FJ. Pregnancy diagnosis and assessment of fetal viability in the dog: a review. J Small Anim Pract. 1988;29(10):647-56. http://dx.doi.org/10.1111/j.1748-5827.1988.tb02164.x.

Barreto JVP, Pertile SFN, Rego FCA, Patelli THC, Nascimento ST, Lorenzetti E, Cunha LFC Fo. Prediction of vitality and survival of newborn lambs using a modified Apgar score. Appl Anim Behav Sci. 2021;238:105281. http://dx.doi.org/10.1016/j.applanim.2021.105281.

Bispham J, Heasman L, Clarke L, Ingleton PM, Stephenson T, Symonds ME. Effect of maternal dexamethasone treatment and ambient temperature on prolactin receptor abundance in brown adipose and hepatic tissue in the foetus and new-born lamb. J Neuroendocrinol. 1999;11(11):849-56. http://dx.doi.org/10.1046/j.1365-2826.1999.00401.x. PMid:10520135.

Bispham J, Budge H, Mostyn A, Dandrea J, Clarke L, Keisler DH, Symonds ME, Stephenson T. Ambient temperature, maternal dexamethasone, and postnatal ontogeny of leptin in the neonatal lamb. Pediatr Res. 2002;52(1):85-90. http://dx.doi.org/10.1203/00006450-200207000-00016. PMid:12084852.

Castro FAB, Ribeiro ELA, Koritiaki NA, Mizubuti IY, Silva LDF, Pereira ES, Pinto AP, Constantino C, Fernandes F Jr. Performance from birth to weaning of Santa Inês lambs born to ewes fed different levels of energy. Semina: Ciênc Agrár. 2012;33(Suppl 2):3379-88. http://dx.doi.org/10.5433/1679-0359.2012v33Supl2p3379.

Dauncey MJ. Thyroid hormones and thermogenesis. Proc Nutr Soc. 1990;49(2):203-15. http://dx.doi.org/10.1079/PNS19900024. PMid:2236086.

Dwyer CM. Behavioural development in the neonatal lamb: effect of maternal and birth-related factors. Theriogenology. 2003;59(3-4):1027-50. http://dx.doi.org/10.1016/S0093-691X(02)01137-8. PMid:12517402.

Dwyer CM. Individual variation in the expression of maternal behaviour: a review of the neuroendocrine mechanisms in the sheep. J Neuroendocrinol. 2008;20(4):526-34. http://dx.doi.org/10.1111/j.1365-2826.2008.01657.x. PMid:18266950.

Dwyer CM, Morgan CA. Maintenance of body temperature in the neonatal lamb: effects of breed, birth weight, and litter size. J Anim Sci. 2006;84(5):1093-101. http://dx.doi.org/10.2527/2006.8451093x. PMid:16612011.

Fagundes GB, Nascimento DM, Santiago MR, Neves CA, Silva CMG, Oba E, Arrivabene M, Cavalcante TV. Response of vital functions, Apgar and cortisol in the prognosis of vigor against neonatal factors of lambs. Pesq Vet Bras. 2019;39(2):155-62. http://dx.doi.org/10.1590/1678-5150-pvb-5731.

Feitosa FLF, Ávila LG, Bovino F, Santos GGF, Mendes LCN, Peiró JR, Perri SHV. Effects of maternal blood gas values corticotherapy of lambs born at term and premature. Pesq Vet Bras. 2017;37(5):521-5. http://dx.doi.org/10.1590/s0100-736x2017000500016.

Forhead AJ, Jellyman JK, Gardner DS, Giussani DA, Kaptein E, Visser TJ, Fowden AL. Differential effects of maternal dexamethasone treatment on circulating thyroid hormone concentrations and tissue deiodinase activity in the pregnant ewe and fetus. Endocrinology. 2007;148(2):800-5. http://dx.doi.org/10.1210/en.2006-1194. PMid:17110425.

Fowden AL, Apatu RS, Silver M. The glucogenic capacity of the fetal pig: developmental regulation by cortisol. Exp Physiol. 1995;80(3):457-67. http://dx.doi.org/10.1113/expphysiol.1995.sp003860. PMid:7640010.

Fowden AL, Li J, Forhead AJ. Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance? Proc Nutr Soc. 1998;57(1):113-22. http://dx.doi.org/10.1079/PNS19980017. PMid:9571716.

Garcia PCR. The arrival of prognostic indices in neonatology. J Pediatr. 2001;77(6):436-7. http://dx.doi.org/10.2223/JPED.346. PMid:14647819.

Gordon I. Controlled reproductioninsheep and goats. Cambridge: CAB International; 1997. 450 p.

Henry M, Neves JP. Manual for andrological examination and evaluation of animal semen. 3a ed. Belo Horizonte: CBRA; 2013. p. 34-7.

Ingoldby L, Jackson P. Induction of parturition in sheep. In Pract. 2001;23(4):228-31. http://dx.doi.org/10.1136/inpract.23.4.228.

Jefferies BC. Body condition scoring and its use in management. Tasman J Agric. 1961;32:19-21.

Jenkin G, Young IR. Mechanisms responsible for parturition; the use of experimental models. Anim Reprod Sci. 2004;82-83:567-81. http://dx.doi.org/10.1016/j.anireprosci.2004.05.010. PMid:15271480.

Kastelic JP, Cook RB, McMahon LR, McAllister TA, McClelland LA, Cheng KJ. Induction of parturition in ewes with dexamethasone or dexamethasone and cloprostenol. Can Vet J. 1996;37(2):101-2. PMid:8640645.

Kiya CK, Biscarde CEA, Silva LFMC, Campos GA, Garcia VFC, Barbosa LP, Resende MV, Bittencourt TCSBC, Gusmão AL. Different times of administration of eCG with or without hCG in a short protocols for FTAI on wooless ewes of semiarid. Magistra [serial on the Internet]. 2017 [cited 2022 Oct 30];26(4):532. Available from: https://www.cabdirect.org/cabdirect/abstract/20153151256

Liggins GC. Premature delivery of foetal lambs infused with glucocorticoids. J Endocrinol. 1969;45(4):515-23. http://dx.doi.org/10.1677/joe.0.0450515. PMid:5366112.

Liggins GC, Howie R. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics. 1972;50(4):515-25. http://dx.doi.org/10.1542/peds.50.4.515. PMid:4561295.

Machado R, Simplício AA. Effect of breed of sire and mating season on the reproductive performance of hairsheep females mated to rams of meat-type breeds. Rev Bras Zootec. 1998;27(1):54-9.

Nowak R, Poindron P. From birth to colostrum: early steps leading to lamb survival. Reprod Nutr Dev. 2006;46(4):431-46. http://dx.doi.org/10.1051/rnd:2006023. PMid:16824451.

Osathanondh R, Chopra IJ, Tulchinsky D. Effects of dexamethasone on fetal and maternal thyroxine, triiodothyronine, reverse triiodothyronine, and thyrotropin levels. J Clin Endocrinol Metab. 1978;47(6):1236-9. http://dx.doi.org/10.1210/jcem-47-6-1236. PMid:263347.

Özalp RG, Yavuz A, Orman A, Seker I, Udum Küçükşen D, Rişvanlı A, Demiral ÖO, Wehrend A. Parturition induction in ewes by a progesterone receptor blocker, aglepristone, and subsequent neonatal survival: preliminary results. Theriogenology. 2017;87:141-7. http://dx.doi.org/10.1016/j.theriogenology.2016.08.016. PMid:27658744.

Regazzi FM, Justo BM, Vidal ABG, Brito MM, Angrimani DSR, Abreu RA, Lúcio CF, Fernandes CB, Vannucchi CI. Prenatal or postnatal corticosteroids favor clinical, respiratory, metabolic outcomes and oxidative balance of preterm lambs corticotherapy for premature neonatal lambs. Theriogenology. 2022;182:129-37. http://dx.doi.org/10.1016/j.theriogenology.2022.02.006. PMid:35168015.

Silva FLR, Figueiredo EAP, Barbieri ME, Simplício AA. Environmental and sire effects on reproductive and growth traits in Santa Inês sheep in Ceará State. Rev Bras Zootec [serial on the Internet]. 1995 [cited 2022 Oct 30];24(4):559-69. Available from: https://ainfo.cnptia.embrapa.br/digital/bitstream/item/41795/1/API-Efeito-de-ambiente.pdf

Silva LP. Clinical trial carried out under the modified APGAR score method aimed at measuring lactate and blood glucose level in neonate lamb [thesis]. Botucatu: Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista “Julio de Mesquita Filho”; 2012 [cited 2022 Oct 30]. Available from: http://hdl.handle.net/11449/89248

Silva LP, Lourenço MLG, Grandi MC, Ulian CM, Sudano MJ, Chiacchio SB. Concentração de lactato sérico em ovelhas e cordeiros mestiços (1/2 Suffolk) nascidos em eutocia. Arq Bras Med Vet Zootec. 2013;65(4):989-94. http://dx.doi.org/10.1590/S0102-09352013000400008.

Silver M. Parturition: spontaneous or induced preterm labour and its consequences for the neonate. Anim Reprod Sci. 1992;28(1-4):441-9. http://dx.doi.org/10.1016/0378-4320(92)90131-V.

Sir C, Bartlewski PM. Analyses of parental and seasonal influences on the synchrony of dexamethasone-induced lambing and lamb characteristics. Livest Sci. 2010;131(1):119-24. http://dx.doi.org/10.1016/j.livsci.2010.03.011.

Tsiligianni T, Ntovolou E, Amiridis GS. Synchronisation of lambing with low doses of dexamethasone in Chios ewes: short communication. Acta Vet Hung. 2008;56(3):393-7. http://dx.doi.org/10.1556/avet.56.2008.3.12. PMid:18828490.

Vassalo FG, Peternelli Silva L, Lourenço MLG, Chiacchio SB. Escore de Apgar: história e importância na medicina veterinária. Rev Bras Reprod Anim [serial on the Internet]. 2014 [cited 2022 Oct 30];38(1):54-9. Available from: http://cbra.org.br/pages/publicacoes/rbra/v38n1/pag54-59%20(RB490%20Vassalo).pdf

Whittle WL, Patel FA, Alfaidy N, Holloway AC, Fraser M, Gyomorey S, Lye SJ, Gibb W, Challis JR. Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production. Biol Reprod. 2001;64(4):1019-32. http://dx.doi.org/10.1095/biolreprod64.4.1019. PMid:11259246.

Zaremba W, Grunert E, Aurich J. Prophylaxis of respiratory distress syndrome in premature calves by administration of dexamethasone or a prostaglandin F2 alpha analogue to their dams before parturition. Am J Vet Res. 1997;58(4):404-7. http://dx.doi.org/10.2460/ajvr.1997.58.04.404. PMid:9099388.

Zoller DK, Vassiliadis PM, Voigt K, Sauter-Louis C, Zerbe H. Two treatment protocols for induction of preterm parturition in ewes: evaluation of the effects on lung maturation and lamb survival. Small Rumin Res. 2015;124:112-9. http://dx.doi.org/10.1016/j.smallrumres.2014.12.015.
 


Submitted date:
10/30/2023

Accepted date:
01/15/2024

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