Animal Reproduction (AR)
https://animal-reproduction.org/article/doi/10.1590/1984-3143-AR2023-0137
Animal Reproduction (AR)
ORIGINAL ARTICLE

Sex-specific efficacy of deslorelin in downregulating reproductive activity in the grey mouse lemur (Microcebus murinus)

Aude Noiret; Fabienne Aujard; Jeremy Terrien

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Abstract

Deslorelin is a GnRH agonist used in veterinary medicine to temporarily inhibit reproduction in domestic animals and is sometimes tested in captive species in zoo to control population or tame aggressive behaviours in males. However, some studies have revealed the inefficacy of deslorelin specifically in males, contrary to females that follow a classic long-term inhibition of the reproductive hypothalamic-pituitary axis through sexual steroid negative feedback. We implanted 5 males and 6 females grey mouse lemurs (Microcebus murinus), long-day breeders that display a complete inhibition of the reproductive system during winter, at the end of the short-day period, a few weeks before the breeding season. Contrary to females, which exhibited a classic inhibitory response to deslorelin, males’ testosterone levels increased as well as their testis size, which suggests a sex-specific sensitivity to the negative feedback of sexual steroids before the mating period. We propose that this sex-imbalance is related to the different life-history of males as opposed to females concerning reproductive tasks and behaviour.

Keywords

seasonal reproduction, deslorelin, grey mouse lemur, sex-specific physiology

References

Aslam H, Schneiders A, Perret M, Weinbauer GF, Hodges JK. Quantitative assessment of testicular germ cell production and kinematic and morphometric parameters of ejaculated spermatozoa in the grey mouse lemur, Microcebus murinus. Reproduction. 2002;123(2):323-32. http://doi.org/10.1530/rep.0.1230323. PMid:11866700.

Aspden WJ, Rodgers RJ, Stocco DM, Scott PT, Wreford NG, Trigg TE, Walsh J, D’Occhio MJ. Changes in testicular steroidogenic acute regulatory (STAR) protein, steroidogenic enzymes and testicular morphology associated with increased testosterone secretion in bulls receiving the luteinizing hormone releasing hormone agonist deslorelin. Domest Anim Endocrinol. 1998;15(4):227-38. http://doi.org/10.1016/S0739-7240(98)00013-7. PMid:9673455.

Ball GF, Ketterson ED. Sex differences in the response to environmental cues regulating seasonal reproduction in birds. Philos Trans R Soc Lond B Biol Sci. 2008;363(1490):231-46. http://doi.org/10.1098/rstb.2007.2137. PMid:17638693.

Bertschinger HJ, Jago M, Nöthling JO, Human A. Repeated use of the GnRH analogue deslorelin to down-regulate reproduction in male cheetahs (Acinonyx jubatus). Theriogenology. 2006;66(6-7):1762-7. http://doi.org/10.1016/j.theriogenology.2006.01.040. PMid:16507319.

Czenze ZJ, Jonasson KA, Willis CKR. Thrifty females, frisky males: winter energetics of hibernating bats from a cold climate. Physiol Biochem Zool. 2017;90(4):502-11. http://doi.org/10.1086/692623. PMid:28641050.

D’Occhio MJ, Fordyce G, Whyte TR, Aspden WJ, Trigg TE. Reproductive responses of cattle to GnRH agonists. Anim Reprod Sci. 2000;60-61:433-42. http://doi.org/10.1016/S0378-4320(00)00078-6. PMid:10844213.

Eymann J, Herbert CA, Thomson BP, Trigg TE, Cooper DW, Eckery DC. Effects of deslorelin implants on reproduction in the common brushtail possum (Trichosurus vulpecula). Reprod Fertil Dev. 2007;19(8):899-909. http://doi.org/10.1071/RD07046. PMid:18076822.

Ferrie GM, Becker KK, Wheaton CJ, Fontenot D, Bettinger T. Chemical and surgical interventions to alleviate intraspecific aggression in male collared lemurs (Eulemur collaris). J Zoo Wildl Med. 2011;42(2):214-21. http://doi.org/10.1638/2009-0193.1. PMid:22946397.

Fontaine C. Long-term contraception in a small implant: a review of Suprelorin (deslorelin) studies in cats. J Feline Med Surg. 2015;17(9):766-71. http://doi.org/10.1177/1098612X15594990. PMid:26323800.

Goericke-Pesch S, Wehrend A. The use of a slow release GnRH-agonist implant in female ferrets in season for oestrus suppression. Schweiz Arch Tierheilkd. 2012;154(11):487-91. http://doi.org/10.1024/0036-7281/a000392. PMid:23117991.

Hamalainen A, Dammhahn M, Aujard F, Eberle M, Hardy I, Kappeler PM, Perret M, Schliehe-Diecks S, Kraus C. Senescence or selective disappearance? Age trajectories of body mass in wild and captive populations of a small-bodied primate. Proc Biol Sci. 2014;2014:281. PMid:25100693.

Herbert CA, Trigg TE, Renfree MB, Shaw G, Eckery DC, Cooper DW. Effects of a gonadotropin-releasing hormone agonist implant on reproduction in a male marsupial. Biol Reprod. 2004;70(6):1836-42. http://doi.org/10.1095/biolreprod.103.025122. PMid:14973259.

Herbison AE. A simple model of estrous cycle negative and positive feedback regulation of GnRH secretion. Front Neuroendocrinol. 2020;57:100837. http://doi.org/10.1016/j.yfrne.2020.100837. PMid:32240664.

Hozer C, Perret M. Photorefractoriness and recovery of photosensitivity in a seasonal nonhuman primate (Microcebus murinus). Int J Primatol. 2023;44(6):1091-109. http://doi.org/10.1007/s10764-023-00380-9.

Junaidi A, Williamson PE, Cummins JM, Martin GB, Blackberry MA, Trigg TE. Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue Deslorelin for reversible long-term contraception in male dogs. Reprod Fertil Dev. 2003;15(6):317-22. http://doi.org/10.1071/RD03039. PMid:14975229.

Key C, Ross C. Sex differences in energy expenditure in non-human primates. Proc Biol Sci. 1999;266(1437):2479-85. http://doi.org/10.1098/rspb.1999.0949. PMid:10693818.

Lane JE, Boutin S, Speakman JR, Humphries MM. Energetic costs of male reproduction in a scramble competition mating system. J Anim Ecol. 2010;79(1):27-34. http://doi.org/10.1111/j.1365-2656.2009.01592.x. PMid:19674182.

Lincoln GA. Long-term stimulatory effects of a continuous infusion of LHRH agonist on testicular function in male red deer (Cervus elaphus). J Reprod Fertil. 1987;80(1):257-61. http://doi.org/10.1530/jrf.0.0800257. PMid:3110411.

Lunn SF, Cowen GM, Morris KD, Fraser HM. Influence of the Gonad on the degree of suppression induced by an lhrh agonist implant in the marmoset monkey. J Endocrinol. 1992;132(2):217-24. http://doi.org/10.1677/joe.0.1320217. PMid:1541921.

Lunn SF, Dixson AF, Sandow J, Fraser HM. Pituitary-testicular function is suppressed by an lhrh antagonist but not by an LHRH agonist in the marmoset monkey. J Endocrinol. 1990;125(2):233-9. http://doi.org/10.1677/joe.0.1250233. PMid:2165119.

Marler CA, Bester-Meredith JK, Trainor BC. Paternal behavior and aggression: endocrine mechanisms and nongenomic transmission of behavior. Adv Stud Behav. 2003;32:263-323. https://doi.org/10.1016/S0065-3454(03)01006-4.

Muller MN. Testosterone and reproductive effort in male primates. Horm Behav. 2017;91:36-51. http://doi.org/10.1016/j.yhbeh.2016.09.001. PMid:27616559.

Padula AM. GnRH analogues--agonists and antagonists. Anim Reprod Sci. 2005;88(1-2):115-26. http://doi.org/10.1016/j.anireprosci.2005.05.005. PMid:15955640.

Perret M, Aujard F. Regulation by photoperiod of seasonal changes in body mass and reproductive function in gray mouse lemurs (Microcebus murinus): differential responses by sex. Int J Primatol. 2001;22(1):5-24. http://doi.org/10.1023/A:1026457813626.

Prendergast BJ. Internalization of seasonal time. Horm Behav. 2005;48(5):503-11. http://doi.org/10.1016/j.yhbeh.2005.05.013. PMid:16026787.

Silvestre FT, Bartolome JA, Kamimura S, Arteche AC, Pancarci SM, Trigg T, Thatcher WW. Postpartum suppression of ovarian activity with a Deslorelin implant enhanced uterine involution in lactating dairy cows. Anim Reprod Sci. 2009;110(1-2):79-95. http://doi.org/10.1016/j.anireprosci.2007.12.015. PMid:18243603.

Terrien J, Gaudubois M, Champeval D, Zaninotto V, Roger L, Riou JF, Aujard F. Metabolic and genomic adaptations to winter fattening in a primate species, the grey mouse lemur (Microcebus murinus). Int J Obes. 2017;42(2):221-30. http://doi.org/10.1038/ijo.2017.195. PMid:28925409.

Trainor BC, Marler CA. Testosterone, paternal behavior, and aggression in the monogamous California mouse (Peromyscus californicus). Horm Behav. 2001;40(1):32-42. http://doi.org/10.1006/hbeh.2001.1652. PMid:11467882.

Trigg TE, Doyle AG, Walsh JD, Swangchan-uthai T. A review of advances in the use of the GnRH agonist deslorelin in control of reproduction. Theriogenology. 2006;66(6-7):1507-12. http://doi.org/10.1016/j.theriogenology.2006.02.037. PMid:16600356.

Walter B, Otzdorff C, Brugger N, Braun J. Estrus induction in Beagle bitches with the GnRH-agonist implant containing 4.7 mg Deslorelin. Theriogenology. 2011;75(6):1125-9. http://doi.org/10.1016/j.theriogenology.2010.11.022. PMid:21220159.

Wedell N, Gage MJG, Parker GA. Sperm competition, male prudence and sperm-limited females. Trends Ecol Evol. 2002;17(7):313-20. http://doi.org/10.1016/S0169-5347(02)02533-8.

Wingfield JC, Hegner RE, Dufty AM Jr, Ball GF. The challenge hypothesis - theoretical implications for patterns of testosterone secretion, mating systems, and breeding strategies. Am Nat. 1990;136(6):829-46. http://doi.org/10.1086/285134.

Young H. The use of deslorelin, a GnRH agonist, to reduce aggression in male chacma baboons (Papio ursinus) to improve animal welfare in a captive setting. Oxford: Oxford Brookes University; 2013.
 


Submitted date:
12/21/2023

Accepted date:
08/20/2024

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