Animal Reproduction (AR)
https://animal-reproduction.org/article/doi/10.1590/1984-3143-AR2024-0063
Animal Reproduction (AR)
Thematic Section: X International Symposium on Animal Biology of Reproduction (ISABR)

The microbiome effect on the female reproductive performance

Ricardo Zanella; Janine de Camargo; Claudia Almeida Scariot; Mariana Groke Marques

Downloads: 2
Views: 192

Abstract

The female reproductive function is coordinated by the endocrine system driven by the hypothalamic-pituitary-gonadal (HPG) axis. While not directly part of the female reproductive system, the gut microbiome plays a crucial role in overall health, including reproductive health. The gut microbiome communicates bidirectionally with the brain via the gut-brain axis, influencing stress levels, mood, and hormonal balance, which can impact reproductive health and fertility. In addition to that, the vaginal and uterine microbiome are directly involved with the reproductive success of farm animals, including female fertility and offspring development. In this paper, we summarize some of the effects of bacterial contamination in the female reproductive tract and their association with reproductive performance in farm animals.

Keywords

vaginal microbial community, reproduction, fertility, 16S rDNA sequencing

References

Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW. Microbiome and human health: current understanding, engineering, and enabling technologies. Chem Rev. 2023;123(1):31-72. http://doi.org/10.1021/acs.chemrev.2c00431. PMid:36317983.

Alves L, de Novais FJ, da Silva AN, Araujo MS, Bernardino T, Osowski GV, Zanella R, Lee Settles M, Holmes MA, Fukumasu H, Ruiz VLA, Zanella AJ. Vaginal microbiota diversity in response to lipopolysaccharide in gilts housed under three housing systems. Front Genet. 2022;13:836962. http://doi.org/10.3389/fgene.2022.836962. PMid:35464863.

Berg G, Rybakova D, Fischer D, Cernava T, Vergès MCC, Charles T, Chen X, Cocolin L, Eversole K, Corral GH, Kazou M, Kinkel L, Lange L, Lima N, Loy A, Macklin JA, Maguin E, Mauchline T, McClure R, Mitter B, Ryan M, Sarand I, Smidt H, Schelkle B, Roume H, Kiran GS, Selvin J, de Souza RSC, Van Overbeek L, Singh BK, Wagner M, Walsh A, Sessitsch A, Schloter M. Microbiome definition re-visited: old concepts and new challenges. Microbiome. 2020;8(1):103. http://doi.org/10.1186/s40168-020-00875-0. PMid:32605663.

Chee WJY, Chew SY, Than LTL. Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microb Cell Fact. 2020;19(1):203. http://doi.org/10.1186/s12934-020-01464-4. PMid:33160356.

Çömlekcioğlu U, Jezierska S, Opsomer G, Pascottini OB. Uterine microbial ecology and disease in cattle: a review. Theriogenology. 2024;213:66-78. http://doi.org/10.1016/j.theriogenology.2023.09.016. PMid:37804686.

Dias NW, Sales A, Timlin C, Pancini S, Currin J, Mercadante VRG. PSII-21 Vaginitis incidence and effects on fertility of beef females enrolled on estrus synchronization protocols using a controlled internal drug release (CIDR) device. Sci Anim Health. 2019;97(Suppl 3):242-242. http://doi.org/10.1093/jas/skz258.491.

Facioli FL, Pedrotti LF, Ataide MW, Da Silva AN, Zanella GC, Cantão ME, Loss CC, Zanella R. Microbiota do trato respiratório inferior de Macacos-Prego (Sapajus Spp.) cativos através de sequenciamento metagenômico. Sci Anim Heal. 2020;8(1):02-20. http://doi.org/10.15210/sah.v8i1.18351.

Han D, Sun P, Hu Y, Wang J, Hua G, Chen J, Shao C, Tian F, Darwish HYA, Tai Y, Yang X, Chang J, Ma Y. The immune barrier of porcine uterine mucosa differs dramatically at proliferative and secretory phases and could be positively modulated by colonizing microbiota. Front Immunol. 2021;12:4943. http://doi.org/10.3389/fimmu.2021.750808. PMid:34917075.

Inversetti A, Zambella E, Guarano A, Dell’Avanzo M, Di Simone N. Endometrial microbiota and immune tolerance in pregnancy. Int J Mol Sci. 2023;24(3):2995. http://doi.org/10.3390/ijms24032995. PMid:36769318.

Kaambo E, Africa C, Chambuso R, Passmore JS. Vaginal microbiomes associated with aerobic vaginitis and bacterial vaginosis. Front Public Health. 2018;6:78. http://doi.org/10.3389/fpubh.2018.00078. PMid:29632854.

Kaluanga Bwanga P, Tremblay-Lemoine PL, Timmermans M, Ravet S, Munaut C, Nisolle M, Henry L. The Endometrial Microbiota. Medicina (Kaunas). 2023;59(9):1540. http://doi.org/10.3390/medicina59091540. PMid:37763663.

Liversedge NH, Turner A, Horner PJ, Keay SD, Jenkins JM, Hull MGR. The influence of bacterial vaginosis on in-vitro fertilization and embryo implantation during assisted reproduction treatment. Hum Reprod. 1999;14(9):2411-5. http://doi.org/10.1093/humrep/14.9.2411. PMid:10469722.

Lof LM, Silva AN, Faciolli FL, Zanella GC, Bondan C, Rodrigues A, Zanella EL, Zanella R. The effect of ceftiofur hydrochloride on pregnancy rates of beef cattle syncronyzed with intravaginal progesterone implants. In: Proceedings of the 10th International Ruminant Reproduction Symposium; 2018; Foz do Iguaçu. Foz do Iguaçu: Animal Reproduction; 2018. v. 15, p. 1131.

Luecke SM, Webb EM, Dahlen CR, Reynolds LP, Amat S. Seminal and vagino-uterine microbiome and their individual and interactive effects on cattle fertility. Front Microbiol. 2022;13:1029128. http://doi.org/10.3389/fmicb.2022.1029128. PMid:36425035.

Maraci Ö, Engel K, Caspers BA. Olfactory communication via microbiota: what is known in birds? Genes (Basel). 2018;9(8):387. http://doi.org/10.3390/genes9080387. PMid:30065222.

Mendez-Figueroa H, Anderson B. Vaginal innate immunity: alteration during pregnancy and its impact on pregnancy outcomes. Expert Rev Obstet Gynecol. 2011;6(6):629-41. http://doi.org/10.1586/eog.11.63.

Ogunrinola GA, Oyewale JO, Oshamika OO, Olasehinde GI. The Human Microbiome and Its Impacts on Health. Int J Microbiol. 2020;2020:8045646. http://doi.org/10.1155/2020/8045646. PMid:32612660.

Pascottini OB, Van Schyndel SJ, Spricigo JFW, Rousseau J, Weese JS, LeBlanc SJ. Dynamics of uterine microbiota in postpartum dairy cows with clinical or subclinical endometritis. Sci Rep. 2020;101(10):1-11. http://doi.org/10.1038/s41598-020-69317-z. PMid:32704012.

Pino A, Rapisarda AMC, Vitale SG, Cianci S, Caggia C, Randazzo CL, Cianci A. A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis. Sci Rep. 2021;11(1):2592. http://doi.org/10.1038/s41598-021-81931-z. PMid:33510271.

Poole RK, Soffa DR, McAnally BE, Smith MS, Hickman-Brown KJ, Stockland EL. Reproductive microbiomes in domestic livestock: insights utilizing 16S rRNA gene amplicon community sequencing. Animals (Basel). 2023;13(3):485. http://doi.org/10.3390/ani13030485. PMid:36766374.

Quadros DL, Zanella R, Bondan C, Zanella GC, Facioli FL, da Silva AN, Zanella EL. Study of vaginal microbiota of Holstein cows submitted to an estrus synchronization protocol with the use of intravaginal progesterone device. Res Vet Sci. 2020;131:1-6. http://doi.org/10.1016/j.rvsc.2020.03.027. PMid:32278134.

Rusch JA, Layden BT, Dugas LR. Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis. Front Endocrinol (Lausanne). 2023;14:1130689. http://doi.org/10.3389/fendo.2023.1130689. PMid:37404311.

Sanglard LP, Schmitz-Esser S, Gray KA, Linhares DCL, Yeoman CJ, Dekkers JCM, Niederwerder MC, Serão NVL. Vaginal microbiota diverges in sows with low and high reproductive performance after porcine reproductive and respiratory syndrome vaccination. Sci Rep. 2020;10(1):3046. http://doi.org/10.1038/s41598-020-59955-8. PMid:32080317.

van Oostrum N, De Sutter P, Meys J, Verstraelen H. Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis. Hum Reprod. 2013;28(7):1809-15. http://doi.org/10.1093/humrep/det096. PMid:23543384.

Walsh RB, LeBlanc SJ, Duffield TF, Kelton DF, Walton JS, Leslie KE. The effect of a progesterone releasing intravaginal device (PRID) on pregnancy risk to fixed-time insemination following diagnosis of non-pregnancy in dairy cows. Theriogenology. 2007;67(5):948-56. http://doi.org/10.1016/j.theriogenology.2006.11.009. PMid:17178146.

Xu S, Dong Y, Shi J, Li Z, Che L, Lin Y, Li J, Feng B, Fang Z, Yong Z, Wang J, Wu D. Responses of vaginal microbiota to dietary supplementation with lysozyme and its relationship with rectal microbiota and sow performance from late gestation to early lactation. Animals (Basel). 2021;11(3):593. http://doi.org/10.3390/ani11030593. PMid:33668266.

Zhang J, Liu M, Ke S, Huang X, Fang S, He M, Fu H, Chen C, Huang L. Gut and vagina microbiota associated with estrus return of weaning sows and its correlation with the changes in serum metabolites. Front Microbiol. 2021;12:690091. http://doi.org/10.3389/fmicb.2021.690091. PMid:34489885.
 


Submitted date:
05/09/2024

Accepted date:
06/05/2024

66b4b4f7a9539507381d1c53 animreprod Articles
Links & Downloads

Anim Reprod

Share this page
Page Sections