An approach to Repeat Breeder Syndrome. Cervical mucus immunoglobulin content does not alter sperm motility

Sofía Lara Villar; Uxía Yáñez; Jacobo Álvarez; Mar Alvariño; Carlos Carmelo Pérez-Marín; Juan José Becerra; Pedro García Herradón; Ana Isabel Peña; Luis Ángel Quintela

doi:10.1590/1984-3143-AR2024-0105

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An approach to Repeat Breeder Syndrome. Cervical mucus immunoglobulin content does not alter sperm motility

Sofía Lara Villar; Uxía Yáñez; Jacobo Álvarez; Mar Alvariño; Carlos Carmelo Pérez-Marín; Juan José Becerra; Pedro García Herradón; Ana Isabel Peña; Luis Ángel Quintela

http://dx.doi.org/10.1590/1984-3143-AR2024-0105 Anim Reprod, vol.22, n2, e20240105, 2025

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Abstract

Repeat breeder (RB) syndrome plays a detrimental role on fertility and economic performance of dairy farms. Regarding its multifactorial origin, it has been stated that an immunological response in the female genital tract may impair sperm viability. Therefore, the aim of this study was to evaluate the concentration of immunoglobulins in cervical mucus of RB cows and its influence on sperm motility. Fifteen fertile cows and 32 RB cows were included in the study. Cervical mucus samples were collected at the time of artificial insemination (AI). The concentration of IgG and IgA was determined by radial immunodiffusion. Sperm motility in cervical mucus was evaluated by CASA system. Our results showed no significant differences between cows with or without RB syndrome regarding the concentration of immunoglobulins in cervical mucus and sperm motility. The only factor affecting sperm motility was time. Consequently, it may be probable that a local immune response against spermatozoa is not one common cause of RB syndrome.

Keywords

repeat breeder cow, dairy cattle, cervical mucus, spermatozoa, immunity

References

Abraham F. An overview on functional causes of infertility in cows. JFIV Reprod Med Genet. 2017;5(2):1000203. http://doi.org/10.4172/2375-4508.1000203.

Brazdova A, Vermachova M, Zidkova J, Ulcova-Gallova Z, Peltre G. Immunodominant semen proteins I: new patterns of sperm proteins related to female immune infertility. Cent Eur J Biol. 2014;8(9):813-8. http://doi.org/10.2478/s11535-013-0214-9.

Jarora V, Cheema R, Bansal A, Gandotra V, Dhindsa S. Status of antisperm antibodies in blood serum and cervical mucus of artificially inseminated crossbred cows in relation to infertility. Anim Sci Report. 2016;10(1):34-40.

Landers DL, Bronson AD, Pavia SC, Stites PD. Reproductive immunology. In Parslow TG, Stites DP, Terr A, editors. Basic and clinical immunology. Norwalk: Appleton & Lange; 1994. p. 200-15.

Lazarevic M, Suljkanovic A, Mickov L, Sabanovic M, Paprikic N, Mlinar S. The influence of antisperm Ig G and Ig A antibodies from cows sera and cervical mucus on bull sperm motility. Acta Vet (Beogr). 2013;63(5-6):499-511. http://doi.org/10.2298/AVB1306499L.

López-Gatius F, Miró J, Sebastián I, Ibarz A, Labèrnia J. Rheological properties of the anterior vaginal fluid from superovulated dairy heifers at estrus. Theriogenology. 1993;40(1):167-80. http://doi.org/10.1016/0093-691X(93)90350-E. PMid:16727303.

Nakano F, Leão R, Esteves S. Insights into the role of cervical mucus and vaginal pH in unexplained infertility. Med Express. 2015;2(2):1-8. http://doi.org/10.5935/MedicalExpress.2015.02.07.

Nowicki A. Embryo transfer as an option to improve fertility in repeat breeder dairy cows. J Vet Res. 2021;65(2):231-7. http://doi.org/10.2478/jvetres-2021-0018. PMid:34250309.

Perez-Marin CC, Molina-Moreno L, Vizuete-Calero G. Clinical approach to the repeat breeder Cow Syndrome. In: Perez-Marin CC, editor. A Bird’s-Eye view of veterinary medicine. Rijeka: InTechOpen; 2012. p. 337-62.

Salasel B, Mokhtari A, Taktaz T. Prevalence, risk factors for and impact of subclinical endometritis in repeat breeder dairy cows. Theriogenology. 2010;74(7):1271-8. http://doi.org/10.1016/j.theriogenology.2010.05.033. PMid:20728926.

Siregar TN, Armansyah T, Panjaitan B, Gholib G, Herrialfian H, Sutriana A, Abidin Z, Reynaldi MA, Razak F, Artaliani Y, Yuswar Y. Changes in cervical mucus as an indicator of fertility in Aceh Cattle. Adv Anim Vet Sci. 2019;7(4):306-14. http://doi.org/10.17582/journal.aavs/2019/7.4.306.314.

Submitted date:
09/02/2024

Accepted date:
02/24/2025

An approach to Repeat Breeder Syndrome. Cervical mucus immunoglobulin content does not alter sperm motility

Sofía Lara Villar; Uxía Yáñez; Jacobo Álvarez; Mar Alvariño; Carlos Carmelo Pérez-Marín; Juan José Becerra; Pedro García Herradón; Ana Isabel Peña; Luis Ángel Quintela

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