Animal Reproduction (AR)
https://animal-reproduction.org/article/doi/10.21451/1984-3143-AR2018-0028
Animal Reproduction (AR)
Conference Paper

Physiological and cellular requirements for successful elongation of the preimplantation conceptus and the implications for fertility in lactating dairy cows

Eduardo de Souza Ribeiro, José Felipe Warmling Spricigo, Murilo Romulo Carvalho, Elvis Ticiani

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Abstract

Elongation of the preimplantation conceptus is a prerequisite for maternal recognition of pregnancy and implantation in ruminants. Failures in this phase of development likely contribute for the subfertility of lactating dairy cows. This review will discuss our current understanding of the physiological and cellular requirements for successful elongation of the preimplantation conceptus and their potential deficiency in subfertile lactating dairy cows. Major requirements include the priming of the endometrium by ovarian steroids, reprogramming of trophectoderm cells at the onset of elongation, and intensification of the crosstalk between elongating conceptus and endometrium. Conceptus elongation and survival in dairy cows does not seem to be affected by lactation per se but seem to be altered in subgroups of cows with endocrine, metabolic and nutritional imbalances or deficiencies. These subgroups of cows include those suffering diseases postpartum, anovular cows enrolled in synchronization programs, and cows with low concentration of circulating steroids and IGF1. Success of conceptus elongation starts long before breeding and entails optimization of health and nutrition programs, especially during the transition period, and might be extended to the supplementation of endocrine and nutritional shortages at the time of breeding. Genetic selection will eventually become more important as researchers unravel the molecular control of reproduction and develop new fertility traits focused on pregnancy survival.

Keywords

conceptus elongation, dairy cow, pregnancy loss.

References

Allrich RD. 1994. Endocrine and neural control of estrus in dairy cows. J Dairy Sci, 77:2738-2744.

Baez GM, Barletta RV, Guenther JN, Gaska JM, Wiltbank MC. 2016. Effect of uterine size on fertility of lactating dairy cows. Theriogenology, 85:1357-1366.

Barbosa L, Oliveira WVC, Pereira MHC, Moreira MB, Vasconcelos CGC, Silper BF, Cerri RLA, Vasconcelos JLM. 2018. Somatic cell count and type of intramammary infection impacts fertility from in vitro produced embryo transfer. Theriogenology, 108: 291-296.

Barnwell CV, Farin PW, Ashwell CM, Farmer WT, Galphin SP Jr, Farin CE. 2016. Differences in mRNA populations of short and long bovine conceptuses on day 15 of gestation. Mol Reprod Dev, 83:424-441.

Bauersachs S, Ulbrich SE, Gross K, Schmidt SE, Meyer HH, Einspanier R, Wenigerkind H, Vermehren M, Blum H, Sinowatz F, Wolf E. 2005. Gene expression profiling of bovine endometrium during the oestrous cycle: detection of molecular pathways involved in functional changes. J Mol Endocrinol, 34:889-908.

Bauersachs S, Wolf E. 2012. Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase. Anim Reprod Sci, 134:84-94.

Bauersachs S, Simintiras CA, Sturmey RG, Krebs S, Bick J, Blum H, Wolf E, Lonergan P, Forde N. 2017. Effect of metabolic status on conceptus-maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome. Biol Reprod, 97:413-425.

Bauman DE, Currie WB. 1980. Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J Dairy Sci, 63:1514-1529.

Berger J, Moller DE. 2002. The mechanisms of action of PPARs. Annu Rev Med, 53:409-435.

Betteridge KJ, Eaglesome MD, Randall GC, Mitchell D. 1980. Collection, description and transfer of embryos from cattle 10-16 days after oestrus. J Reprod Fertil, 59:205-216.

Bindon BM. 1971. Role of progesterone in implantation in the sheep. Aust J Biol Sci, 24:149-158.

Bisinotto RS, Chebel R, Santos JE. 2010. Follicular wave of the ovulatory follicle and not cyclic status influences fertility of dairy cows. J Dairy Sci, 93:3578-3587.

Bisinotto RS, Ribeiro ES, Lima FS, Martinez N, Greco LF, Barbosa L, Bueno PP, Scagion LFS, Thatcher WW, Santos JEP. 2013. Targeted progesterone supplementation improves fertility in lactating dairy cows without a corpus luteum at the initiation of the timed artificial insemination protocol. J Dairy Sci, 96:2214-2225.

Bisinotto RS, Lean IJ, Thatcher WW, Santos JE. 2015. Meta-analysis of progesterone supplementation during timed artificial insemination programs in dairy cows. J Dairy Sci, 98:2472-2487.

Block J, Bonilla L, Hansen PJ. 2010. Efficacy of in vitro embryo transfer in lactating dairy cows using fresh or vitrified embryos produced in a novel embryo culture medium. J Dairy Sci, 93: 5234-5242.

Boshier DP, Fairlough RJ, Holloway H. 1987. Assessment of sheep blastocyst effects on neutral lipids in the uterine caruncular epithelium. J Reprod Fert, 79:569-573.

Brinsfield TH, Hawk HW. 1973. Control by progesterone of the concentration of lipid droplets in epithelial cells of the sheep endometrium. J Anim Sci, 36:919-22.

Brooks KE, Burns GW, Spencer TE. 2015. Peroxisome proliferator activator receptor gamma (PPARG) regulates conceptus elongation in sheep. Biol Reprod, 92:42. doi: 10.1095/biolreprod.114.123877.

Butler WR. 2003. Energy balance relationships with follicular development, ovulation and fertility in postpartum dairy cows. Livest Prod Sci, 83:211-218.

Butler ST, Marr AL, Pelton SH, Radcliff RP, Lucy MC, Butler WR. 2003. Insulin restores GH responsiveness during lactation-induced negative energy balance in dairy cattle: effects on expression of IGF-I and GH receptor 1A. J Endocrinol, 176:205–217.

Butler ST. 2014. Genetic control of reproduction in dairy cows. Reprod Fertil Dev, 26:1-11.

Cerri RL, Thompson IM, Kim IH, Ealy AD, Hansen PJ, Staples CR, Li JL, Santos JE, Thatcher WW. 2012. Effects of lactation and pregnancy on gene expression of endometrium of Holstein cows at day 17 of the estrous cycle or pregnancy. J Dairy Sci, 95:5657-5675.

Carnegie JA, McCully ME, Robertson HA. 1985. The early development of the sheep trophoblast and the involvement of cell death. Am J Anat, 174:471-488.

Chagas LM, Bass JJ, Blache D, Burke CR, Kay JK, Lindsay DR, Lucy MC, Martin GB, Meier S, Rhodes FM, Roche JR, Thatcher WW, Webb R. 2007. Invited review: new perspectives on the roles of nutrition and metabolic priorities in the subfertility of high-producing dairy cows. J Dairy Sci, 90:4022-4032.

Chebel RC, Demetrio DG, Metzger J. 2008. Factors affecting success of embryo collection and transfer in large dairy herds. Theriogenology, 69:98-106.

Clemente M, Lopez-Vidriero I, O’Gaora P, Mehta JP, Forde N, Gutierrez-Adan A, Lonergan P, Rizos D. 2011. Transcriptome changes at the initiation of elongation in the bovine conceptus. Biol Reprod, 85:285-295.

Cole JB, Null DJ, VanRaden PM. 2016. Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility. J Dairy Sci, 99:7274-7288.

Costello LM, O'Boyle P, Godkin JD, Diskin MG, Hynes AC, Morris DG. 2010. Retinol-binding protein (RBP), retinol and beta-carotene in the bovine uterus and plasma during the oestrous cycle and the relationship between systemic progesterone and RBP on day 7. Reprod Fertil Dev, 22:1198-1205.

Drackley JK. 1999. ADSA Foundation Scholar Award. Biology of dairy cows during the transition period: the final frontier? J Dairy Sci, 82:2259-2273.

Ferraz PA, Burnley C, Karanja J, Viera-Neto A, Santos JE, Chebel RC, Galvao KN. 2016. Factors affecting the success of a large embryo transfer program in Holstein cattle in a commercial herd in the southeast region of the United States. Theriogenology, 86:1834-1841.

Foote WD, Gooch LD, Pope AL, Casida LE. 1957. The maintenance of early pregnancy in ovariectomised ewes by injections of ovarian hormones. J Anim Sci, 16:986-989.

Forde N, Carter F, Fair T, Crowe MA, Evans AC, Spencer TE, Bazer FW, McBride R, Boland MP, O'Gaora P, Lonergan P, Roche JF. 2009. Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle. Biol Reprod, 81:784-794.

Forde N, Spencer TE, Bazer FW, Song G, Roche JF, Lonergan P. 2010. Effect of pregnancy and progesterone concentration on expression of genes encoding for transporters or secreted proteins in the bovine endometrium. Physiol Genomics, 41:53-62.

Forde N, Beltman ME, Duffy GB, Duffy P, Mehta JP, O'Gaora P, Roche JF, Lonergan P, Crowe MA. 2011. Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation. Biol Reprod, 84:266-278.

Forde N, McGettigan PA, Mehta JP, O'Hara L, Mamo S, Bazer FW, Spencer TE, Lonergan P. 2014. Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle. Reproduction, 147:575-587.

Forde N, Simintiras C A, Sturmey R G, Graf A, Wolf E, Blum H, Lonergan P. 2017. Effect of lactation on conceptus-maternal interactions at the initiation of implantation in cattle: I. Effects on the conceptus transcriptome and amino acid composition of the uterine luminal fluid. Biol Reprod, 97:798-809.

França MR, da Silva MIS, Pugliesi G, Hoeck VV, Binelli M. 2017. Evidence of endometrial amino acid metabolism and transport modulation by peri-ovulatory endocrine profiles driving uterine receptivity. J Anim Sci Biotechnol, 8:54. doi: 10.1186/s40104-017-0185-1.

Gao H, Wu G, Spencer TE, Johnson GA, Bazer FW. 2009. Select nutrients in the ovine uterine lumen. II. glucose transporters in the uterus and peri-implantation conceptuses. Biol Reprod, 80:94-104.

Garrett JE, Geisert RD, Zavy MT, Morgan GL. 1988. Evidence for maternal regulation of early conceptus growth and development in beef cattle. Reproduction, 84:437-446.

Geary TW, Burns GW, Moraes JG, Moss JI, Denicol AC, Dobbs KB, Ortega MS, Hansen PJ, Wehrman ME, Neibergs H, O'Neil E, Behura S, Spencer TE. 2016. Identification of beef heifers with superior uterine capacity for pregnancy. Biol Reprod, 95:47. doi: 10.1095/biolreprod.116.141390.

Geisert RD, Morgan GL, Short EC Jr, Zavy MT. 1992. Endocrine events associated with endometrial function and conceptus development in cattle. Reprod Fertil Dev, 4:301-305.

Goff JP. 2004. Macromineral disorders of the transition cow. Vet Clin North Am Food Anim Pract, 20:471-494.

Groebner AE, Rubio-Aliaga I, Schulke K, Reichenbach HD, Daniel H, Wolf E, Meyer HH, Ulbrich SE. 2011. Increase of essential amino acids in the bovine uterine lumen during preimplantation development. Reproduction, 141:685-695.

Han Y, Penagaricano F. 2016. Unravelling the genomic architecture of bull fertility in Holstein cattle. BMC Genet, 17:143. doi: 10.1186/s12863-016-0454-6.

Hillegass J, Lima FS, Sa Filho MF, Santos JE. 2008. Effect of time of artificial insemination and supplemental estradiol on reproduction of lactating dairy cows. J Dairy Sci, 91:4226-4237.

Hue I, Degrelle SA, Campion E, Renard JP. 2007. Gene expression in elongating and gastrulating embryos from ruminants. Soc Reprod Fertil Suppl, 64:365-377.

Hue I, Degrelle SA, Turenne N. 2012. Conceptus elongation in cattle: genes, models and questions. Anim Reprod Sci, 134:19-28.

Hugentobler SA, Diskin MG, Leese HJ, Humpherson PG, Watson T, Sreenan JM, Morris DG. 2007. Amino acids in oviduct and uterine fluid and blood plasma during the estrous cycle in the bovine. Mol Reprod Dev, 74:445-454.

Itoh T, Fairall L, Amin K, Inaba Y, Szanto A, Balint BL, Nagy L, Yamamoto K, Schwabe JW. 2008. Structural basis for the activation of PPARgamma by oxidized fatty acids. Nat Struct Mol Biol, 15:924-931.

Kenyon AG, Lopes G Jr, Mendonca LG, Lima JR, Bruno RG, Denicol AC, Chebel RC. 2012. Ovarian responses and embryo survival in recipient lactating Holstein cows treated with equine chorionic gonadotropin. Theriogenology, 77:400-411.

Kenyon AG, Mendonca LG, Lopes G Jr, Lima JR, Santos JE, Chebel RC. 2013. Minimal progesterone concentration required for embryo survival after embryo transfer in lactating Holstein cows. Anim Reprod Sci, 136:223-230.

Kim J, Sato M, Li Q, Lydon JP, DeMayo FJ, Bagchi IC, Bagchi MK. 2008. Peroxisome proliferator-activated receptor γ is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice. Mol Cel Biol, 28:1770-1782.

Kim J, Erikson DW, Burghardt RC, Spencer TE, Wu G, Bayless KJ, Johnson GA, Bazer FW. 2010. Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells. Matrix Biol, 29:369-382.

Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM. 1997. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA, 94:4318-4323.

Le Roith D, Bondy C, Yakar S, Liu JL, Butler A. 2001. The somatomedin hypothesis: 2001. Endocr Rev, 22:53-74.

LeBlanc SJ, Herdt TH, Seymour WM, Duffield TF, Leslie KE. 2004. Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease. J Dairy Sci, 87:609-619.

Lonergan P, Forde N. 2014. Maternal-embryo interaction leading up to the initiation of implantation of pregnancy in cattle. Animal, 8(suppl. 1):64-69.

Madsen CA, Perry GA, Mogck CL, Daly RF, MacNeil MD, Geary TW. 2015. Effects of preovulatory estradiol on embryo survival and pregnancy establishment in beef cows. Anim Reprod Sci, 158:96-103.

Maillo V, Rizos D, Besenfelder U, Havlicek V, Kelly AK, Garrett M, Lonergan P. 2012. Influence of lactation on metabolic characteristics and embryo development in postpartum Holstein dairy cows. J Dairy Sci, 95:3865-3876.

Mamo S, Mehta JP, McGettigan P, Fair T, Spencer TE, Bazer FW, Lonergan P. 2011. RNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation. Biol Reprod, 85:1143-1151.

Mamo S, Mehta JP, Forde N, McGettigan P, Lonergan P. 2012. Conceptus-endometrium crosstalk during maternal recognition of pregnancy in cattle. Biol Reprod, 87:6,1-9. doi: 10.1095/biolreprod.112.099945.

Marinho LS, Sanches BV, Rosa CO, Tannura JH, Rigo AG, Basso AC, Pontes JH, Seneda MM. 2015. Pregnancy Rates to Fixed Embryo Transfer of Vitrified IVP Bos indicus, Bos taurus or Bos indicus x Bos taurus Embryos. Reprod Domest Anim, 50:807-811.

Meier S, Peterson AJ, Mitchell MD, Littlejohn M, Walker CG, Roche JR. 2009. Genetic strain and reproductive status affect endometrial fatty acid concentrations. J Dairy Sci, 92:3723-3730.

Mikkola M, Andersson M, Taponen J. 2015. Transfer of cattle embryos produced with sex-sorted semen results in impaired pregnancy rate and increased male calf mortality. Theriogenology, 84:1118-1122.

Miller BG, Moore NW. 1976. Effects of progesterone and oestradiol on endometrial metabolism and embryo survival in the ovariectomized ewe. Theriogenology, 6:636. (Abstract).

Miller BG, Moore NW, Murphy L, Stone GM. 1977. Early pregnancy in the ewe: effects of oestradiol and progesterone on uterine metabolism and on embryo survival. Aust J Biol Sci, 30:279-288.

Mitko K, Ulbrich SE, Wenigerkind H, Sinowatz F, Blum H, Wolf E, Bauersachs S. 2008. Dynamic changes in messenger RNA profiles of bovine endometrium during the oestrous cycle. Reproduction, 135:225-240.

Monteiro PL Jr, Ribeiro ES, Maciel RP, Dias AL, Sole E Jr, Lima FS, Bisinotto RS, Thatcher WW, Sartori R, Santos JE. 2014. Effects of supplemental progesterone after artificial insemination on expression of interferon-stimulated genes and fertility in dairy cows. J Dairy Sci, 97:4907-4921.

Monteiro PL Jr, Nascimento AB, Pontes GCS, Fernandes GO, Melo LF, Wiltbank MC, Sartori R. 2015. Progesterone supplementation after ovulation: Effects on corpus luteum function and on fertility of dairy cows subjected to AI or ET Theriogenology, 84:125-124.

Moore NW, Rowson LE. 1959. Maintenance of pregnancy in ovariectomized ewes by means of progesterone. Nature, 184(suppl. 18):1410.

Moore NW, Shelton JN. 1964. Egg transfer in sheep. effect of degree of synchronization between donor and recipient, age of egg, and site of transfer on the survival of transferred eggs. J Reprod Fertil, 7:145-152.

Moore NM. 1985. The use of embryo transfer and steroid hormone replacementtherapy in the study of prenatal mortality. Theriogenology, 23:121-128.

Moraes JGN, Behura SK, Geary TW, Hansen PJ, Neibergs HL, Spencer TE. 2018. Uterine influences on conceptus development in fertility-classified animals. Proc Natl Acad Sci USA, 115:E1749-E1758.

Mullen MP, Elia G, Hilliard M, Parr MH, Diskin MG, Evans AC, Crowe MA. 2012a. Proteomic characterization of histotroph during the preimplantation phase of the estrous cycle in cattle. J Proteome Res, 11:3004-3018.

Mullen MP, Forde N, Parr MH, Diskin MG, Morris DG, Nally JE, Evans AC, Crowe MA. 2012b. Alterations in systemic concentrations of progesterone during the early luteal phase affect RBP4 expression in the bovine uterus. Reprod Fertil Dev, 24:715-722.

Nagy L, Tontonoz P, Alvarez JGA, Chen H, Evans RM. 1998. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 93:229-240.

Okumu LA, Forde N, Fahey AG, Fitzpatrick E, Roche JF, Crowe MA, Lonergan P. 2010. The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus. Reproduction, 140:143-153.

Ortega MS, Denicol AC, Cole JB, Null DJ, Hansen PJ. 2016. Use of single nucleotide polymorphisms in candidate genes associated with daughter pregnancy rate for prediction of genetic merit for reproduction in Holstein cows. Anim Genet, 47:288-297.

Parr MH, Crowe MA, Lonergan P, Evans AC, Rizos D, Diskin MG. 2014. Effect of exogenous progesterone supplementation in the early luteal phase post-insemination on pregnancy per artificial insemination in Holstein-Friesian cows. Anim Reprod Sci, 150:7-14.

Pereira MH, Sanches CP, Guida TG, Rodrigues AD, Aragon FL, Veras MB, Borges PT, Wiltbank MC, Vasconcelos JL. 2013. Timing of prostaglandin F2alpha treatment in an estrogen-based protocol for timed artificial insemination or timed embryo transfer in lactating dairy cows. J Dairy Sci, 96:2837-2846.

Pereira MHC, Wiltbank MC, Vasconcelos JLM. 2016. Expression of estrus improves fertility and decreases pregnancy losses in lactating dairy cows that receive artificial insemination or embryo transfer. J Dairy Sci, 99:2237-2247.

Pereira MHC, Wiltbank MC, Guida TG, Lopes FR, Jr., Vasconcelos JLM. 2017. Comparison of 2 protocols to increase circulating progesterone concentration before timed artificial insemination in lactating dairy cows with or without elevated body temperature. J Dairy Sci, 100:8455-8470.

Pinaffi FLV, Araujo ER, Silva LA, Ginther OJ. 2017. Color-Doppler signals of blood flow in the corpus luteum and vascular perfusion index for ovarian and uterine arteries during expansion of the allantochorion in Bos taurus heifers. Theriogenology, 102:35-43.

Reese ST, Pereira MHC, Edwards JL, Vasconcelos JLM, Pohler KG. 2018. Pregnancy diagnosis in cattle using pregnancy associated glycoprotein concentration in circulation at day 24 of gestation. Theriogenology, 106:178-185.

Rhoads ML, Meyer JP, Kolath SJ, Lamberson WR, Lucy MC. 2008. Growth hormone receptor, insulin-like growth factor (IGF)-1, and IGF-binding protein-2 expression in the reproductive tissues of early postpartum dairy cows. J Dairy Sci, 91:1802-1813.

Rhodes FM, McDougall S, Burke CR, Verkerk GA, Macmillan KL. 2003. Treatment of cows with an extended postpartum anestrous interval. J. Dairy Sci. 86:1876-1894.

Ribeiro ES, Cerri RL, Bisinotto RS, Lima FS, Silvestre FT, Greco LF, Thatcher WW, Santos JE. 2011. Reproductive performance of grazing dairy cows following presynchronization and resynchronization protocols. J Dairy Sci, 94:4984-4996.

Ribeiro ES, Galvão K, Thatcher WW, Santos JEP. 2012. Economic aspects of applying reproductive technologies to dairy herds. Anim Reprod, 9:370-387.

Ribeiro ES, Lima FS, Greco LF, Bisinotto RS, Monteiro AP, Favoreto M, Ayres H, Marsola RS, Martinez N, Thatcher WW, Santos JE. 2013. Prevalence of periparturient diseases and effects on fertility of seasonally calving grazing dairy cows supplemented with concentrates. J Dairy Sci, 96:5682-5697.

Ribeiro ES, Bisinotto RS, Lima FS, Greco LF, Morrison A, Kumar A, Thatcher WW, Santos JE. 2014a. Plasma anti-Mullerian hormone in adult dairy cows and associations with fertility. J Dairy Sci, 97:6888-6900.

Ribeiro ES, Bruno RG, Farias AM, Hernandez-Rivera JA, Gomes GC, Surjus R, Becker LF, Birt A, Ott TL, Branen JR, Sasser RG, Keisler DH, Thatcher WW, Bilby TR, Santos JE. 2014b. Low doses of bovine somatotropin enhance conceptus development and fertility in lactating dairy cows. Biol Reprod, 90:10. doi: 10.1095/biolreprod.113.114694.

Ribeiro ES, Greco LF, Bisinotto RS, Lima FS, Thatcher WW, Santos JE. 2016a. Biology of preimplantation conceptus at the onset of elongation in dairy cows. Biol Reprod, 94:97. doi: 10.1095/biolreprod.115.134908.

Ribeiro ES, Gomes GC, Greco LF, Cerri RLA, Vieira-Neto A, Monteiro PLJ Jr, Lima FS, Bisinotto RS, Thatcher WW, Santos JEP. 2016b. Carryover effect of postpartum inflammatory diseases on developmental biology and fertility in lactating dairy cows. J Dairy Sci, 99:2201-2220.

Ribeiro ES, Monteiro APA, Bisinotto RS, Lima FS, Greco LF, Ealy AD, Thatcher WW, Santos JEP. 2016c. Conceptus development and transcriptome at preimplantation stages in lactating dairy cows of distinct genetic groups and estrous cyclic statuses. J Dairy Sci, 99:4761-4777.

Ribeiro ES, Santos JE, Thatcher WW. 2016d. Role of lipids on elongation of the preimplantation conceptus in ruminants. Reproduction, 152:R115-126.

Ribeiro ES, Carvalho MR. 2017. Impact and mechanisms of inflammatory diseases on embryonic development and fertility in cattle. Animal Reproduction, 14:589-600.

Ribeiro ES. 2018. Lipids as regulators of conceptus development:Implications for metabolic regulation of reproduction in dairy cattle. J Dairy Sci, 101:3630-3641.

Rivera FA, Mendonca LG, Lopes G Jr, Santos JE, Perez RV, Amstalden M, Correa-Calderon A, Chebel RC. 2011. Reduced progesterone concentration during growth of the first follicular wave affects embryo quality but has no effect on embryo survival post transfer in lactating dairy cows. Reproduction, 141:333-342.

Robinson RS, Mann GE, Gadd TS, Lamming GE, Wathes DC. 2000. The expression of the IGF system in the bovine uterus throughout the oestrous cycle and early pregnancy. J Endocrinol, 165:231-243.

Rodney RM, Celi P, Scott W, Breinhild K, Lean IJ. 2015. Effects of dietary fat on fertility of dairy cattle: a meta-analysis and meta-regression. J Dairy Sci, 98:5601-5620.

Romero JJ, Liebig BE, Broeckling CD, Prenni JE, Hansen TR. 2017. Pregnancy-induced changes in metabolome and proteome in ovine uterine flushings. Biol Reprod, 97:273-287.

Santos JE, Thatcher WW, Chebel RC, Cerri RL, Galvao KN. 2004. The effect of embryonic death rates in cattle on the efficacy of estrus synchronization programs. Anim Reprod Sci, 82-83:513-535.

Santos JE, Bilby TR, Thatcher WW, Staples CR, Silvestre FT. 2008. Long chain fatty acids of diet as factors influencing reproduction in cattle. Reprod Domest Anim, 43:23-30.

Santos JE, Rutigliano HM, Sá Filho MF. 2009. Risk factors for resumption of postpartum estrous cycles and embryonic survival in lactating dairy cows. Anim Reprod Sci, 110:207-221.

Santos JE, Bisinotto RS, Ribeiro ES, Lima FS, Greco LF, Staples CR, Thatcher WW. 2010. Applying nutrition and physiology to improve reproduction in dairy cattle. Soc Reprod Fertil Suppl, 67:387-403.

Santos JE, Bisinotto RS, Ribeiro ES. 2016. Mechanisms underlying reduced fertility in anovular dairy cows. Theriogenology, 86:254-262.

Sawai K, Kageyama S, Moriyasu S, Hirayama H, Minamihashi A, Onoe S. 2007. Changes in the mRNA transcripts of insulin-like growth factor ligand, receptors and binding proteins in bovine blastocysts and elongated embryos derived from somatic cell nuclear transfer. J Reprod Dev, 53:77-86.

Schinckel PG. 1954. The effect of the presence of the ram on the ovarian activity of the ewe. Aust J Agric Res, 5:465-469.

Sellars CB, Dalton JC, Manzo R, Day J, Ahmadzadeh A. 2006. Time and incidence of ovulation and conception rates after incorporating estradiol cypionate into a timed artificial insemination protocol. J Dairy Sci, 89:620-626.

Shimizu T, Krebs S, Bauersachs S, Blum H, Wolf E, Miyamoto A. 2010. Actions and interactions of progesterone and estrogen on transcriptome profiles of

the bovine endometrium. Physiol Genomics, 42A:290-300.

Simmons RM, Erikson DW, Kim J, Burghardt RC, Bazer FW, Johnson GA, Spencer TE. 2009. Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation. Endocrinology, 150:4295-4305.

Souza AH, Gumen A, Silva EP, Cunha AP, Guenther JN, Peto CM, Caraviello DZ, Wiltbank MC. 2007. Supplementation with estradiol-17beta before the last gonadotropin-releasing hormone injection of the Ovsynch protocol in lactating dairy cows. J Dairy Sci, 90:4623-4634.

Spencer TE, Bazer FW. 1995. Temporal and spatial alterations in uterine estrogen receptor and progesterone receptor gene expression during the estrous cycle and early pregnancy in the ewe. Biol Reprod, 53:1527-1543.

Spencer TE, Johnson GA, Burghardt RC, Bazer FW. 2004. Progesterone and placental hormone actions on the uterus: insights from domestic animals. Biol Reprod, 71:2-10.

Spencer TE, Forde N, Dorniak P, Hansen TR, Romero JJ, Lonergan P. 2013. Conceptus-derived prostaglandins regulate gene expression in the endometrium prior to pregnancy recognition in ruminants. Reproduction, 146:377-387.

Sponchiado M, Gomes NS, Fontes PK, Martins T, Del Collado M, Pastore AA, Pugliesi G, Nogueira MFG, Binelli M. 2017. Pre-hatching embryo-dependent and -independent programming of endometrial function in cattle. PLoS One, 12:e0175954.

Stewart BM, Block J, Morelli P, Navarette AE, Amstalden M, Bonilla L, Hansen PJ, Bilby TR. 2011. Efficacy of embryo transfer in lactating dairy cows during summer using fresh or vitrified embryos produced in vitro with sex-sorted semen. J Dairy Sci, 94:3437-3445.

Thatcher WW, Macmillan KL, Hansen PJ, Drost M. 1989. Concepts for regulation of corpus luteum function by the conceptus and ovarian follicles to improve fertility. Theriogenology, 31:149-164.

Thatcher WW, Moreira F, Santos JE, Mattos RC, Lopes FL, Pancarci SM, Risco CA. 2001. Effects of hormonal treatments on reproductive performance and embryo production. Theriogenology, 55:75-89.

Thiam, AR, Farese Jr RV, Walther TC. 2013. The biophysics and cell biology of lipid droplets. Nat Rev Mol Cell Biol, 14:775-786.

Thompson IM, Cerri RL, Kim IH, Ealy AD, Hansen PJ, Staples CR, Thatcher WW. 2012. Effects of lactation and pregnancy on metabolic and hormonal responses and expression of selected conceptus and endometrial genes of Holstein dairy cattle. J Dairy Sci, 95:5645-5656.

Ulbrich SE, Schulke K, Groebner AE, Reichenbach HD, Angioni C, Geisslinger G, Meyer HH. 2009. Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. Reproduction, 138:371-382.

Valour D, Degrelle SA, Ponter AA, Giraud-Delville C, Campion E, Guyader-Joly C, Richard C, Constant F, Humblot P, Ponsart C, Hue I, Grimard B. 2014. Energy and lipid metabolism gene expression of D18 embryos in dairy cows is related to dam physiological status. Physiol Genomics, 46:39-56.

Wales RG, Cuneo CL. 1989. Morphology and chemical analysis of the sheep conceptus from the 13th to the 19th day of pregnancy. Reprod Fertil Dev, 1:31-39.

Wang J, Guillomot M, Hue I. 2009. Cellular organization of the trophoblastic epithelium in elongating conceptuses of ruminants. C R Biol, 332:986-997.

Wiltbank MC, Gumen A, Sartori R. 2002. Physiological classification of anovulatory conditions in cattle. Theriogenology, 57:21-52.

Wiltbank MC, Lopez H, Sartori R, Sangsritavong S, Gumen A. 2006. Changes in reproductive physiology of lactating dairy cows due to elevated steroid metabolism. Theriogenology, 65:17-29.

Wiltbank MC, Souza AH, Carvalho PD, Cunha AP, Giordano JO, Fricke PM, Baez GM, Diskin MG. 2014. Physiological and practical effects of progesterone on reproduction in dairy cattle. Animal, 8(suppl. 1):70-81.

Wiltbank MC, Baez GM, Garcia-Guerra A, Toledo MZ, Monteiro PL, Melo LF, Ochoa JC, Santos JE, Sartori R. 2016. Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows. Theriogenology, 86:239-253.

Wordinger RJ, Dickey JF, Ellicott AR. 1977. Histochemical evaluation of the lipid droplet content of bovine oviductal and endometrial epithelial cells. J Reprod Fertil, 49:113-114.

Yang X, Zhang W, Chen Y, Li Y, Sun L, Liu Y, Liu M, Yu M, Li X, Han J, Duan Y. 2016. Activation of peroxisome proliferator-activated receptor γ (PPARγ) and CD36 protein expression. J Biol Chem, 291:15108-15118.

Yaseen MA, Wrenzycki C, Herrmann D, Carnwath JW, Niemann H. 2001. Changes in the relative abundance of mRNA transcripts for insulin-like growth factor (IGF-I and IGF-II) ligands and their receptors (IGF-IR/IGF-IIR) in preimplantation bovine embryos derived from different in vitro systems. Reproduction, 122:601-610.

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