Understanding the uterine environment in early pregnancy in cattle: How have the omics enhanced our knowledge?
Constantine A. Simintiras, Niamh Forde
Abstract
Early pregnancy loss in cattle can be attributed to a myriad of sources. One key factor that can influence early pregnancy success or loss is the influence and interactions between the maternal environment and the developing embryo/conceptus. Recent advances in high-throughput ‘omics' technologies coupled with improved bioinformatics capabilities represent a promising avenue for enhancing our understanding of fundamental developmental events – which would have direct agricultural, veterinary, and economic benefits. Thusly this review revolves around recent applications of advanced transcriptomic, proteomic, and metabolomic analyses within a bovine uterine secretomic and interactomic context, with an overriding aim to highlight the advantages of these emerging fields whilst identifying areas for improvement, consideration, and further research and development.
Keywords
References
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