Animal Reproduction (AR)
https://animal-reproduction.org/journal/animreprod/article/doi/10.21451/1984-3143-2017-AR887
Animal Reproduction (AR)
Original Article

Anti-Müllerian hormone (AMH) as a predictor of antral follicle population in heifers

Christopher Júnior Tavares Cardoso; Jair Sábio de Oliveira Junior; Henrique Kischel; Wilian Aparecido Leite da Silva; Elielton Dias da Silva Arruda; Mirela Brochado Souza-Cáceres; Fernanda Amarante Mendes de Oliveira; Ériklis Nogueira; Guilherme de Paula Nogueira; Fabiana de Andrade Melo-Sterza

Downloads: 3
Views: 1384

Abstract

Antral follicular population (AFP) and anti-Müllerian hormone (AMH) concentration are strongly associated. Thus, analyzing AMH concentration is a reliable method to predict animals with high AFP, an important feature to select donor cows for embryos and oocytes. However, not much is known about this parameter in heifers, particularly in crossbred animals. The aim of this study was to assess AFP in heifers and cows and its relation to serum AMH levels. Bos taurus indicus cows (36–60-months-old; n = 30) and heifers (12–14-months-old; n = 17) of the same breed were evaluated. A single procedure of follicular counting was performed by ultrasound for each animal. Random sampling was performed to analyze serum AMH concentration. Cows showed higher AFP than heifers; nonetheless, plasma AMH concentration did not differ between the categories. A high correlation of AFP with plasma AMH concentration was observed in Girolando heifers. Thus, it is suggested that AMH concentration could be a reliable and less invasive method for selecting heifers with high AFP.

Keywords

bovine, follicles, selection donors

References

Baldrighi J , Sa Filho MF , Batista EO , Lopes RN , Visintin JA , Baruselli PS , Assumpcao ME . 2014 : Anti-Mullerian hormone concentration and antral ovarian follicle population in Murrah heifers compared to Holstein and Gyr kept under the same management . Reprod Domest Anim , 49 : 1015 - 1020 .

Baruselli OS , Batista EOS , Vieira LM , Souza AH . 2015 . Relationship between follicle population, AMH concentration and fertility in cattle . Anim Reprod , 12 : 487 - 497 .

Batista EO , Macedo GG , Sala RV , Ortolan MD , Sa Filho MF , Del Valle TA , Jesus EF , Lopes RN , Renno FP , Baruselli PS . 2014 . Plasma antimullerian hormone as a predictor of ovarian antral follicular population in Bos indicus (Nelore) and Bos taurus (Holstein) heifers . Reprod Domest Anim , 49 : 448 - 452 .

Bayeux BM , Carvalho LM , Watanabe YF , Mingoti RD , Oliveira AdS , Chiba MO , Azrak AJ , Castro PMdN , Souza AH , Baruselli PS . 2016 . Efeito da categoria (pré-púberes, púberes e prenhes) na produção in vitro de embriões de novilhas da raça holandesa [ in portuguese ]. In: XXX Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões , 25 a 27 de agosto, 2016 , Foz do Iguaçu . Anais ... Foz do Iguaçu: Paraná, Brasil , p. 256 . Abstract .

Borges CRA , Azevedo M , Lima IA , Brasil LHA , Ferreira MA . 2012 . Heterogeneous genetic cows of three genetic groups in feedlot system in the state of Pernambuco, Brazil. Acta Sci Anim Sci , 34 : 91 - 96 .

Cate RL , Mattaliano RJ , Hession C , Tizard R , Farber NM , Cheung A , Ninfa EG , Frey AZ , Gash DJ , Chow EP , Fisher RA , Bertonis JM , Torres G , Wallner BP , Ramachandran KL , Ragin RC , Manganaro TF , Maclaughlin DT , Donahoe PK . 1986 . Isolation of the Bovine and Human Genes for Mullerian Inhibiting Substance and Expression of the Human-Gene in Animal-Cells . Cell , 45 : 685 - 698 .

Cushman RA , Allan MF , Kuehn LA , Snelling WM , Cupp AS , Freetly HC . 2009 . Evaluation of antral follicle count and ovarian morphology in crossbred beef cows: investigation of influence of stage of the estrous cycle, age, and birth weight . J Anim Sci , 87 : 1971 - 1980 .

Durlinger AL , Gruijters MJ , Kramer P , Karels B , Ingraham HA , Nachtigal MW , Uilenbroek JT , Grootegoed JA , Themmen AP . 2002 . Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary . Endocrinology , 143 : 1076 - 1084 .

Evans AC , Mossa F , Fair T , Lonergan P , Butler ST , Zielak-Steciwko AE , Smith GW , Jimenez-Krassel F , Folger JK , Ireland JL , Ireland JJ . 2010 . Causes and consequences of the variation in the number of ovarian follicles in cattle . Soc Reprod Fertil Suppl , 67 : 421 - 429 .

Fanchin R , Schonauer LM , Righini C , Guibourdenche J , Frydman R , Taieb J . 2003 . Serum anti-Mullerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3 . Hum Reprod , 18 : 323 - 327 .

Ghanem N , Jin JI , Kim SS , Choi BH , Lee KL , Ha AN , Song SH , Kong IK . 2016 . The Anti-Mullerian Hormone Profile is Linked with the In Vitro Embryo Production Capacity and Embryo Viability after Transfer but Cannot Predict Pregnancy Outcome . Reprod Domest Anim , 51 : 301 - 310 .

Gobikrushanth M , Dutra PA , Bruinje TC , Colazo MG , Butler ST , Ambrose DJ . 2017 . Repeatability of antral follicle counts and anti-Mullerian hormone and their associations determined at an unknown stage of follicular growth and an expected day of follicular wave emergence in dairy cows . Theriogenology , 92 : 90 - 94 .

Guerreiro BM , Batista EO , Vieira LM , Sa Filho MF , Rodrigues CA , Castro Netto A , Silveira CR , Bayeux BM , Dias EA , Monteiro FM , Accorsi M , Lopes RN , Baruselli PS . 2014 . Plasma anti-mullerian hormone: an endocrine marker for in vitro embryo production from Bos taurus and Bos indicus donors . Domest Anim Eendocrinol , 49 : 96 - 104 .

Houghton P , Lemenager R , Hendrix K , Moss G , Stewart T. 1990 . Effects of body composition, pre-and postpartum energy intake and stage of production of energy utilization by beef cows . J Anim Sci , 68 : 1447 - 1456 .

Ireland JJ , Smith GW , Scheetz D , Jimenez-Krassel F , Folger JK , Ireland JL , Mossa F , Lonergan P , Evans AC . 2011 . Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-Mullerian hormone as a diagnostic marker for fertility and causes of variation in the ovarian reserve in cattle . Reprod Fertili Dev , 23 : 1 - 14 .

Monniaux D , Clemente N , Touze JL , Belville C , Rico C , Bontoux M , Picard JY , Fabre S . 2008 . Intrafollicular steroids and anti-mullerian hormone during normal and cystic ovarian follicular development in the cow . Biol Reprod , 79 : 387 - 396 .

Monniaux D , Drouilhet L , Rico C , Estienne A , Jarrier P , Touze J. L , Sapa J , Phocas F , Dupont J , Dalbies-Tran R , Fabre S. 2012 . Regulation of anti-Mullerian hormone production in domestic animals . Reprod Fertil Dev , 25 : 1 - 16 .

Monniaux D , Rico C , Larroque H , Dalbies-Tran R , Medigue C , Clement F , Fabre S. 2010 . Anti-Mullerian hormone, an endocrine predictor of the response to ovarian stimulation in the bovine species . Gynecol Obstet Fertil , 38 : 465 - 470 .

Morotti F , Barreiros TRR , Machado FZ , Gonzylez SM , Marinho LSR , Seneda MM . 2015 . Is the number of antral follicles an interesting selection criterium for fertility in cattle? Anim Reprod , 12 : 479 - 486 .

Oliveira Junior JS , Cardoso CJT , Silva WAL , Kischel H , Souza MB , Andrade ER , Nogueira E , Silva-Santos KC , Seneda MM , de Andrade Melo-Sterza F . 2015 . Antral follicles population in heifers and cows of Nelore and Girolando breeds . Semina: Ciênc Agrár , 36 : 3741 - 3750 .

Rico C , Fabre S , Medigue C , di Clemente N , Clement F , Bontoux M , Touze JL , Dupont M , Briant E , Remy B , Beckers JF , Monniaux D . 2009 . Anti-mullerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow . Biol Reprod , 80 : 50 - 59 .

Rico C , Medigue C , Fabre S , Jarrier P , Bontoux M , Clement F , Monniaux D. 2011 . Regulation of anti-Mullerian hormone production in the cow: a multiscale study at endocrine, ovarian, follicular, and granulosa cell levels . Biol Reprod , 84 : 560 - 571 .

Rodrigues AS , Oliveira SN , Loiola MVG , Ferraz PA , Chalhoub M , Bittencourt RF , Araujo EAB , Bittencourt TCBdS , Ribeiro Filho AL . 2015 . Antral follicle count in Nelore females subjected to fixed-time artificial insemination . Ciênc Rural , 45 : 711 - 717 .

Silva-Santos KC , Santos GM , Koetz Junior C , Morotti F , Siloto LS , Marcantonio TN , Urbano MR , Oliveira RL , Lima DC , Seneda MM . 2014 a : Antral follicle populations and embryo production-in vitro and in vivo-of Bos indicus-taurus donors from weaning to yearling ages . Reprod Domest Anim , 49 : 228 - 232 .

Silva-Santos KC , Siloto LS , Santos GM , Morotti F , Marcantonio TN , Seneda MM . 2014 b . Comparison of antral and preantral ovarian follicle populations between Bos indicus and Bos indicus-taurus cows with high or low antral follicles counts . Reprod Domest Anim , 49 : 48 - 51 .

Silva MVGB , Martins MF , Paiva LC , Cembranelli MAR , Arbex WA , Santos KCL . 2014 . Programa de Melhoramento Genético da Raça Girolando Avaliação Genética de Vacas [ in portuguesse ]. Documentos 173 - Embrapa Gado de Leite , Juiz de Fora, MG .

Visser JA , Durlinger AL , Peters IJ , van den Heuvel ER , Rose UM , Kramer P , de Jong FH , Themmen AP . 2007 . Increased oocyte degeneration and follicular atresia during the estrous cycle in anti-Mullerian hormone null mice . Endocrinology , 148 : 2301 - 2308 .

Weenen C , Laven JS , Von Bergh AR , Cranfield M , Groome NP , Visser JA , Kramer P , Fauser BC , Themmen AP . 2004 . Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment . Mol Hum Reprod , 10 : 77 - 83 .

 

 

 

5b756c920e882569438068b1 animreprod Articles
Links & Downloads

Anim Reprod

Share this page
Page Sections