Angiogenic factors and ovarian follicle development
J.B. Bruno, M.H.T. Matos, R.N. Chaves, J.J.H. Celestino, M.V.A. Saraiva, I.B. Lima-Verde, V.R. Araújo, J.R. Figueiredo
Anim Reprod, vol.6, n2, p.371-379, 2009
Ovarian follicles require an adequate blood supply for oxygen, nutrients and hormones, in addition to eliminating CO2 and other metabolites. Acquisition of an adequate vascular supply is probably a limiting step in the selection and maturation of the dominant follicle. In this way, there is a progressive interest in the study of the growth factors involved in the angiogenic process. In addition, a better understanding about the mechanisms that regulate the expression and action of these factors could be a key point to increase the reproductive performance in females. Therefore, this review aims to summarize current data on the importance of the pro- and anti-angiogenic growth factors which regulate angiogenesis in ovarian follicle development.
angiogenesis, follicle, growth factors, ovary