Animal Reproduction (AR)
Animal Reproduction (AR)

Angiogenic factors and ovarian follicle development

J.B. Bruno, M.H.T. Matos, R.N. Chaves, J.J.H. Celestino, M.V.A. Saraiva, I.B. Lima-Verde, V.R. Araújo, J.R. Figueiredo

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Ovarian follicles require an adequate blood supply for oxygen, nutrients and hormones, in addition to eliminating CO2 and other metabolites. Acquisition of an adequate vascular supply is probably a limiting step in the selection and maturation of the dominant follicle. In this way, there is a progressive interest in the study of the growth factors involved in the angiogenic process. In addition, a better understanding about the mechanisms that regulate the expression and action of these factors could be a key point to increase the reproductive performance in females. Therefore, this review aims to summarize current data on the importance of the pro- and anti-angiogenic growth factors which regulate angiogenesis in ovarian follicle development.


angiogenesis, follicle, growth factors, ovary
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